| Date | Home | Frames | Points | | Points | Frames | Away |
| 23/11/2021 | Deakin, Martin (34) - Kings Club B | 0 | 0 | v | 0 | 0 | Jones, Nick (13) - Irlam Catholic |
| 23/11/2021 | Melia, Keith (32) - G.E.S.M. A | 0 | 0 | v | 0 | 0 | Allan, Roy (38) - Penketh Cons A |
| 23/11/2021 | Brown, Scott (0286) (11) - Walkers A | 0 | 0 | v | 0 | 0 | Shaw, Danny (15) - Kings Club A |
| 23/11/2021 | Miller, Steve (16) - Monks A | 0 | 0 | v | 0 | 0 | Williams, Kev (23) - Kings Club B |
| 23/11/2021 | Davies, Louis (8) - Woolston A | 0 | 0 | v | 0 | 0 | Taylor, Alan (-2) - Irlam Catholic |
| 23/11/2021 | Taylor, Mark (17) - Alford D | 0 | 0 | v | 0 | 0 | Bamber, Harry (38) - Kings Club A |
| 23/11/2021 | Ward, Dave (3) - Irlam Catholic | 0 | 0 | v | 0 | 0 | Small, John (15) - Warrington Cons B |
| 23/11/2021 | Wilkinson, Mark (-6) - Woolston A | 0 | 0 | v | 0 | 0 | Whibley, James (28) - Kings Club A |
| 23/11/2021 | Evans, Dave (21) - Penketh Cons B | 0 | 0 | v | 0 | 0 | Babington, Louis (20) - Alford A |
| 23/11/2021 | McNamee Snr, Danny (31) - Warrington Cons B | 0 | 0 | v | 0 | 0 | Beaton, Ian (13) - The Grange |
| 23/11/2021 | Withers, Mike (16) - Kings Club C | 0 | 0 | v | 0 | 0 | Giblin, Chris (19) - Penketh Cons B |
| 23/11/2021 | Grimshaw, Mark (39) - St Benedicts A | 0 | 0 | v | 0 | 0 | Lunn, Gary (-11) - Woolston A |