| Player | Team | Break | Opponent | Team | H/A | Date |
| Garnett, Stewart (10) | G.E.S.M. A | 64 | Taylor, Mark (17) | Alford D | Home | 24/03/2022 |
| Lunn, Gary (-11) | Woolston A | 58 | Cheng, Nick (4) | Kings Club C | Home | 03/03/2022 |
| Dean, Paul (-26) | G.E.S.M. A | 56 | Morley, Steve (29) | Alford D | Home | 24/03/2022 |
| Lunn, Gary (-11) | Woolston A | 55 | Ward, Dave (3) | Irlam Catholic | Away | 02/12/2021 |
| Seymour, Andy (-15) | Bridgewater A | 53 | Veldhoven, Keith (-12) | Irlam Steel | Home | 16/12/2021 |
| Leathem, Mark (15) | Woolston A | 52 | Brown, John (29) | Alford D | Away | 10/02/2022 |
| Seymour, Andy (-15) | Bridgewater A | 52 | Cheng, Nick (4) | Kings Club C | Home | 14/10/2021 |
| Dean, Paul (-26) | G.E.S.M. A | 50 | Ashley, Ray (29) | Penketh Cons B | Home | 10/03/2022 |
| Giblin, Chris (19) | Penketh Cons B | 49 | Brown, Wes (16) | Walkers B | Away | 18/11/2021 |
| Barton, John (-1) | G.E.S.M. A | 48 | Molyneux, Ian (40) | The Grange | Home | 21/10/2021 |
| Whittaker, Tyler (22) | Kings Club A | 48 | Sargeant, Andy (22) | Irlam Catholic | Away | 24/03/2022 |
| Veldhoven, Keith (-12) | Irlam Steel | 48 | Whittaker, Tyler (22) | Kings Club A | Away | 28/10/2021 |
| Corns, Les (0) | Kings Club C | 44 | Burlinson, Billy (29) | Alford D | Home | 16/12/2021 |
| Dean, Paul (-26) | G.E.S.M. A | 44 | Veldhoven, Keith (-12) | Irlam Steel | Away | 17/03/2022 |
| Morley, Matt (-4) | Alford D | 43 | Fitzpatrick, John (6) | Bridgewater A | Home | 06/01/2022 |
| Hall, Brian (-22) | The Grange | 42 | Camilleri, Dean (6) | Irlam Catholic | Away | 24/02/2022 |
| Barton, John (-1) | G.E.S.M. A | 41 | Doyle, Pat (17) | Irlam Steel | Away | 17/03/2022 |
| Corns, Les (0) | Kings Club C | 41 | Sweeney, Ian (24) | Bridgewater A | Home | 27/01/2022 |
| Beaton, James (-17) | The Grange | 40 | Garnett, Stewart (10) | G.E.S.M. A | Home | 03/02/2022 |
| Giblin, James (-4) | Penketh Cons B | 39 | Beaton, James (-17) | The Grange | Home | 06/01/2022 |
| Horobin, Scott (5) | Woolston A | 39 | Brown, Jordan (31) | Walkers B | Away | 04/11/2021 |
| Hall, Brian (-22) | The Grange | 38 | Davies, Louis (8) | Woolston A | Away | 09/12/2021 |
| Morley, Matt (-4) | Alford D | 38 | Delaney, Mike (15) | Monks A | Away | 10/03/2022 |
| Veldhoven, Keith (-12) | Irlam Steel | 38 | Doan, Steve (48) | Penketh Cons B | Home | 04/11/2021 |
| Whittaker, Tyler (22) | Kings Club A | 38 | Knox, Dean (16) | Irlam Steel | Away | 10/02/2022 |
| Morley, Matt (-4) | Alford D | 38 | McKenna, Dave (7) | Irlam Catholic | Away | 30/09/2021 |
| Leathem, Mark (15) | Woolston A | 37 | Brown, John (29) | Alford D | Away | 10/02/2022 |
| Hall, Brian (-22) | The Grange | 37 | Brown, Ryan (48) | Walkers B | Home | 14/10/2021 |
| Lunn, Gary (-11) | Woolston A | 37 | Gordon, Lee (16) | The Grange | Home | 09/12/2021 |
| Barton, John (-1) | G.E.S.M. A | 37 | Manfredi, Renzo (16) | Eagle Sports | Home | 10/02/2022 |
| Bate, Phil (-11) | Woolston A | 37 | Owen, Mike (10) | Irlam Steel | Home | 03/02/2022 |
| Cook, Dexter (2) | Monks A | 37 | Shaw, Danny (15) | Kings Club A | Away | 14/10/2021 |
| Beaton, James (-17) | The Grange | 36 | Aspinall, Wayne (11) | Eagle Sports | Home | 10/03/2022 |
| Veldhoven, Keith (-12) | Irlam Steel | 36 | Bate, Phil (-11) | Woolston A | Home | 21/10/2021 |
| Corns, Les (0) | Kings Club C | 36 | Brown, Ryan (48) | Walkers B | Home | 21/04/2022 |
| Horobin, Scott (5) | Woolston A | 36 | Crosby, Dave (28) | Walkers B | Home | 17/02/2022 |
| Robinson, Jeff (-15) | G.E.S.M. A | 36 | Jones, Glyn (32) | Alford D | Home | 24/03/2022 |
| Wisedale, Pat (-10) | G.E.S.M. A | 36 | Seymour, Andy (-15) | Bridgewater A | Home | 07/10/2021 |
| McKenna, Phil (-4) | Irlam Catholic | 36 | Sutcliffe, Tony (3) | Eagle Sports | Home | 18/11/2021 |
| Lunn, Gary (-11) | Woolston A | 36 | Taylor, Alan (-2) | Irlam Catholic | Home | 17/03/2022 |
| Barton, John (-1) | G.E.S.M. A | 35 | Bailey, Craig (26) | Walkers B | Away | 31/03/2022 |
| Morley, Matt (-4) | Alford D | 35 | Barton, John (-1) | G.E.S.M. A | Away | 24/03/2022 |
| Dean, Paul (-26) | G.E.S.M. A | 35 | Brown, Wes (16) | Walkers B | Away | 31/03/2022 |
| Cooper, Gary (6) | Alford D | 35 | Davies, Louis (8) | Eagle Sports | Away | 14/10/2021 |
| Lunn, Gary (-11) | Woolston A | 35 | Hanratty, Jamie (24) | Penketh Cons B | Away | 27/01/2022 |
| Sutcliffe, Tony (3) | Eagle Sports | 35 | Tatlock, Gary (-7) | G.E.S.M. A | Home | 28/10/2021 |
| Newton, Jon (6) | The Grange | 33 | Bate, Phil (-11) | Woolston A | Home | 24/03/2022 |
| Morley, Matt (-4) | Alford D | 33 | Black, P (-10) | Monks A | Home | 25/11/2021 |
| Hall, Brian (-22) | The Grange | 33 | Manfredi, Renzo (16) | Eagle Sports | Home | 10/03/2022 |
| Miller, Steve (16) | Monks A | 33 | Wilkinson, Mark (-6) | Woolston A | Home | 13/01/2022 |
| Cook, Dexter (2) | Monks A | 32 | Aspinall, Wayne (11) | Eagle Sports | Home | 02/12/2021 |
| Garnett, Stewart (10) | G.E.S.M. A | 32 | Cook, Dexter (2) | Monks A | Home | 06/01/2022 |
| Duffy, Paul (19) | Alford D | 32 | Corns, Les (0) | Kings Club C | Home | 31/03/2022 |
| Dolly, Stephen (11) | Kings Club A | 32 | Duffy, Paul (19) | Alford D | Away | 04/11/2021 |
| Aspinall, Wayne (11) | Eagle Sports | 32 | Myatt, Geoff (40) | Bridgewater A | Away | 24/02/2022 |
| Robinson, Jeff (-15) | G.E.S.M. A | 32 | Ure, Gordon (13) | Monks A | Home | 06/01/2022 |
| Livingstone, Scott (4) | G.E.S.M. A | 32 | Veldhoven, Keith (-12) | Irlam Steel | Home | 02/12/2021 |
| Dodd, Steve (-1) | Woolston A | 31 | Ashley, Ray (29) | Penketh Cons B | Home | 14/10/2021 |
| Whittaker, Tyler (22) | Kings Club A | 31 | Crosby, Dave (28) | Walkers B | Home | 11/11/2021 |
| Sutcliffe, Tony (3) | Eagle Sports | 31 | Crosby, Dave (28) | Walkers B | Home | 03/02/2022 |
| Cheng, Nick (4) | Kings Club C | 31 | Dolly, Stephen (11) | Kings Club A | Away | 25/11/2021 |
| Whittaker, Tyler (22) | Kings Club A | 31 | Hall, Brian (-22) | The Grange | Home | 31/03/2022 |
| Lunn, Gary (-11) | Woolston A | 31 | Taylor, Alan (-2) | Irlam Catholic | Home | 17/03/2022 |
| Bate, Phil (-11) | Woolston A | 31 | Warren, John (2) | The Grange | Home | 09/12/2021 |
| Hall, Brian (-22) | The Grange | 30 | Davies, Louis (8) | Woolston A | Away | 09/12/2021 |
| Wilkinson, Mark (-6) | Woolston A | 30 | Evans, Dave (21) | Penketh Cons B | Home | 14/10/2021 |
| Corns, Les (0) | Kings Club C | 30 | Herriot, Glen (25) | Penketh Cons B | Away | 17/03/2022 |
| McKenna, Phil (-4) | Irlam Catholic | 30 | Ormesher, Danny (29) | Kings Club C | Home | 03/02/2022 |
| Bate, Phil (-11) | Woolston A | 30 | Tatlock, Gary (-7) | G.E.S.M. A | Away | 24/02/2022 |
| Wisedale, Philip (5) | G.E.S.M. A | 30 | Taylor, Scott (28) | Kings Club A | Home | 18/11/2021 |
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