| Round | Date | H/A | Brk Max | Brks Over 30 | W/L | Pts | v | Pts | Away | Team | Brks Over 30 | Brk Max |
| Week 1 | 30/09/2021 | Away | | | Won | 104 | v | 91 | Walker, Stuart (44) | Woolston C | | |
| Week 2 | 07/10/2021 | Home | | | Lost | 75 | v | 78 | Deakin, Martin (34) | Kings Club B | | |
| Week 3 | 14/10/2021 | Away | | | Won | 94 | v | 73 | McNamee Jr, Danny (22) | Warrington Cons B | | |
| Week 4 | 21/10/2021 | Home | | | Lost | 81 | v | 91 | Savage, Daniel (26) | Penketh Cons A | | |
| Week 5 | 28/10/2021 | Away | | | Lost | 64 | v | 119 | Grimshaw, Mark (39) | St Benedicts A | | |
| Week 6 | 04/11/2021 | Home | | | Lost | 68 | v | 87 | Ward, Jonny (35) | Deaf Social A | | |
| Week 7 | 11/11/2021 | Away | | | Won | 88 | v | 62 | Wray, Paul (50) | Deaf Social B | | |
| Week 8 | 18/11/2021 | Home | | | Lost | 60 | v | 75 | Taylor, Chris (6) | Alford B | | |
| Week 9 | 25/11/2021 | Away | | | Won | 89 | v | 72 | Dodd, Kevin (34) | Alford A | | |
| Week 10 | 02/12/2021 | Home | | | Lost | 73 | v | 101 | Lappin, Joshua (45) | Walkers A | | |
| Week 11 | 09/12/2021 | Away | | | Lost | 74 | v | 87 | Delooze, Michael (26) | The Hatter | | |
| Week 12 | 16/12/2021 | Home | | | Lost | 56 | v | 80 | Ford, Ste (18) | G.E.S.M. B | | |
| Week 14 | 13/01/2022 | Home | | | Won | 102 | v | 55 | Walker, Stuart (44) | Woolston C | | |
| Week 15 | 20/01/2022 | Away | | | Lost | 87 | v | 100 | Moran, Conor (26) | Kings Club B | | |
| Week 16 | 27/01/2022 | Home | | | Won | 96 | v | 52 | Davies, Andy (23) | Warrington Cons B | | |
| Week 17 | 03/02/2022 | Away | | | Lost | 58 | v | 108 | Wilcock, Tony (41) | Penketh Cons A | | |
| Week 18 | 10/02/2022 | Home | | | Lost | 64 | v | 74 | Thorpe, Kiel (25) | St Benedicts A | | |
| Week 19 | 17/02/2022 | Away | | | Lost | 79 | v | 93 | Bradburn, Richard (23) | Deaf Social A | | |
| Week 20 | 24/02/2022 | Home | | | Lost | 82 | v | 86 | Johnson, Anthony (42) | Deaf Social B | | |
| Week 21 | 03/03/2022 | Away | | | Lost | 70 | v | 73 | Tsang, Phil (-10) | Alford B | | |
| Week 22 | 10/03/2022 | Home | | | Won | 99 | v | 69 | Gibbons, Joe (41) | Alford A | | |
| Week 23 | 17/03/2022 | Away | | | Lost | 69 | v | 76 | Ruddy, Charlie (20) | Walkers A | | |
| Week 24 | 24/03/2022 | Home | | | Lost | 79 | v | 82 | O'Brien, David (21) | The Hatter | | |
| Week 24 | 24/03/2022 | Home | | | Lost | 60 | v | 70 | Chisnall, Lee (22) | The Hatter | | |
| Week 25 | 31/03/2022 | Away | | | Lost | 54 | v | 95 | Acton, Mark (-1) | G.E.S.M. B | 1 | 36 |
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